PERIPHERAL VASCULAR PERFUSION SCANNING

Perfusion lung scanning in obliterative pulmonary hypertension.

Lung perfusion scanning in hepatic cirrhosis.

Abnormal lung perfusion scans using radioactive particles were found in five out of six cases of hepatic cirrhosis with arterial hypoxaemia. None had clinical evidence of cardiopulmonary disease or signs of pulmonary embolism on arteriography. The scan defects are probably caused by a disorder of the pulmonary microvasculature, which may show regional variation in severity.

Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation.

To determine the impact of progressive elevations in peripheral vascular disease (PVD) risk on microvascular function, we utilized eight rat models spanning "healthy" to "high PVD risk" and used a multiscale approach to interrogate microvascular function and outcomes: healthy: Sprague-Dawley rats (SDR) and lean Zucker rats (LZR); mild risk: SDR on high-salt diet (HSD) and SDR on high-fructose d...

Microvascular function in the peripheral vascular bed during ischaemia and oxygen-free perfusion.

OBJECTIVES To determine the influence of acute ischaemia and absence of leukocytes on the microvascular function and capillary permeability in skeletal muscle. DESIGN Prospective, open study. SETTING University Department of Vascular Surgery and Institute of Medical Physiology. MATERIALS AND METHODS Ten isolated cat gastrocnemius muscles were perfused with oxygen-free Ringer-albumin solut...

Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model.

We examined the involvement of nitric oxide (NO) and/or endothelium-derived hyperpolarizing factor (EDHF) in decreasing peripheral vascular resistance in the rat hind limb perfusion model and analyzed the identity of EDHF in this model. The potency of carbachol (CCh) to produce relaxation was quantitatively similar to sodium nitroprusside (SNP). CCh-induced relaxation was abolished after endoth...